By Ivor Benjamin MD FACC FAHA, Robert C. Griggs MD FACP FAAN, Edward J Wing MD FACP FIDSA, J. Gregory Fitz MD

Students, citizens, and teachers swear through Andreoli and Carpenter’s Cecil necessities of Medicine since it provides simply the correct amount of knowledge, simply definitely the right means. This up-to-date version has been revised to supply the most up-tp-date, easy-to-digest evaluate of inner medication. finished but concise, it makes a speciality of the high-yield center wisdom very important to these tested in or simply coming into the field.

  • Excellent photos and photographs vividly illustrate the looks and medical positive aspects of disease.
  • Full-color design makes soaking up and protecting info as easy as possible.
  • Highlights the middle principles of medication and the way they practice to sufferer care.

  • Focused revision reduces the variety of pages from the former edition, providing extra high-yield center details in an obtainable format.
  • Clear, concise writing sort facilitates comprehension, whereas new figures, tables, and end-of-chapter references improve clarity and retention.
  • Consistent format offers readability. each one part describes key physiology and biochemistry, via finished bills of the ailments of the organ method or box lined within the chapters.
  • Brand-new chapters on Thrombosis and Head and Neck Infections be certain assurance of the themes so much correct to every reader’s needs.
  • Student seek advice book model incorporated with purchase. This superior publication adventure includes web-only extras, extra figures and tables, medical photographs, radiologic photos, video techniques, imaging experiences, and audio recordings, as well as the fully searchable text and the entire images from the book.

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Extra resources for Andreoli and Carpenter's Cecil Essentials of Medicine

Sample text

Human cells have 23 pairs of chromosomes, and each pair contains a unique sequence of genetic information. In the human genome, about 6 × 109 nucleotides, or 3 × 109 pairs of nucleotides, associate in the double helix. The specificity of DNA is determined by the base sequence that is stored in 2 complementary form in the double-helical structure. It facilitates correction of sequence errors and provides a mechanistic basis for replication of information during cell division. Each DNA strand provides a template for replication, which is accomplished by the action of DNA-dependent polymerases that unwind the double-helical DNA and copy each single strand with remarkable fidelity.

Dominance and recessiveness refer to the nature of the heritability of a genetic trait and correlate with the number of alleles affected at a given locus. If a mutation in a single allele determines the phenotype, the mutation is said to be dominant; that is, the heterozygous state conveys the clinical phenotype to the individual. If a mutation is necessary at both alleles to determine the phenotype, the mutation is said to be recessive; that is, only the homozygous state conveys the clinical phenotype to the individual.

Large deletions that can incorporate many kilobase pairs and many genes can be visualized with fluorescence in situ hybridization (FISH), a technique in which a segment of cloned DNA is labeled with a fluorescent tag and hybridized to chromosomal DNA. With the deletion of the segment of interest from the genome, the chromosomal DNA fails to fluoresce in the corresponding chromosomal location. Advances in molecular medicine have elucidated the mechanisms of carcinogenesis and revolutionized the diagnosis and treatment of neoplastic diseases.

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