By Colin J Barrow (Editor), David H. Small (Editor)

Contemporary advances in genetics and mind biochemistry element to the Abeta peptide because the significant perpetrator in inflicting neurodegeneration in Alzheimer’s ailment (AD). This ebook summarizes present wisdom of the Abeta peptide and its position in advert. Written by way of experts during this fast-paced sector, the booklet covers primary biochemical experiences in this peptide, the genetic impression on Abeta expression and processing, and numerous advert healing concepts that focus on Abeta.

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Extra resources for Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research

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75. , Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat Med, 1996. 2(8):864-870. 76. , Alzheimer’s disease is a synaptic failure. Science, 2002. 298(5594):789-791. 77. , Toward a comprehensive theory for Alzheimer’s disease. Hypothesis: Alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci, 2000.

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104(5):432-434. 183. , Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer’s disease pedigrees. Science, 2000. 290(5500):2303-2304. 184. , The amyloid precursor protein locus and very-late-onset 26 Alzheimer’s disease. Am J Hum Genet, 2001. 69(4):895-899. 185. , Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology, 1993. 43(8):1467-1472. 186. , Causative and susceptibility genes for Alzheimer’s disease: a review.

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